Eighth Edition   ©2015


Jeremy M. Berg , John L. Tymoczko (Carleton College) , Gregory J. Gatto, Jr. (GlaxoSmithKline) , Lubert Stryer (Stanford University School of Medicine)

  • ISBN-10: 1-4641-2610-0; ISBN-13: 978-1-4641-2610-9; Format: Cloth Text, 1232 pages

Integrated Text and Media
  • Metabolic Map.  EXPLORE icons throughout the text denote topics where students are encouraged to take visual tours through the Metabolic Map within SaplingPlus to better see the connections between concepts and how pathways interrelate. With this interactive tool, students can navigate and zoom between overviews and detailed views of the most commonly taught metabolic pathways. Embedded Tutorials take students through the pathways step by step. Such intimate interaction helps students visualize concepts in isolation as well as understand how concepts are interconnected, thereby helping students to grasp the ramifications of those connections. Assessment questions align with the interactive map to help students verify their understanding of the pathways and connections among the pathways.
    *Metabolic Pathways include: glycolysis, gluconeogenesis, the citric acid cycle, oxidative phosphorylation, the pentose phosphate pathway, fatty acid synthesis, the urea cycle, and ß oxidation.
  • NEW! Tagged Learning Objectives for resources included in SaplingPlus and an instructor guide make finding and assigning problems by learning objective easy and efficient.
  • Living Figures. The Living Figure icon sends readers to a SaplingPlus location where the same molecule represented in the figure can be found in manipulatable format.
  • Animated Technique Videos. Whenever an EOC problem refers to a technique for which we have an animation, there is a link to those animations on SaplingPlus.
Promote Effective Problem Solving
  • Problem-Solving Practice. Every chapter of Biochemistry provides numerous opportunities for students to practice problem-solving skills and apply the concepts described in the text. End-of-chapter problems vary in presentation and degree of difficulty to accommodate different learning styles and to coach students to develop different ways of looking at problem solving.
  • Specialized Problems. There are four categories of problems to address higher-level problem-solving skills: mechanism problems ask students to suggest or describe a chemical mechanism; data interpretation problems require students to draw conclusions from data taken from real research papers; chapter integration problems require students to connect concepts across chapters; and (NEW!) think/pair/share problems provide instructors with tools to use this cooperative learning technique to encourage critical thinking and problem solving.
  • Sapling End-of-Chapter Problems.  More than 250 questions from the end- of-chapter problems are incorporated into the Sapling online homework platform. The problems include unique module types, targeted feedback, and detailed solutions, all of which will assist in student success and assessment reporting. 
  • Case Studies. Introduce students to a biochemical mystery and allow them to determine what investigations will solve it. 9 new case studies bringing total to 16.
  • Problem-Solving Videos. With diagrams, graphs, and narration, these videos walk students through problems on topics that typically prove difficult, helping them understand the right approach to the solution.
Tools and Resources for Active Learning
  • NEW! Think/Pair/Share Questions. Found in every end-of-chapter problem set, these new questions are designed to facilitate group thinking and motivate peer-to-peer instruction and problem-solving discussion.
  • Clicker Questions for Think/Pair/Share Questions with instructor notes and PowerPoint Questions and Biochemistry in Focus Questions.
  • Blast Database Activity. An activity to introduce students to bioinformatic techniques that they would use in a research setting.
  • Case Studies. Each case study introduces students to a biochemical mystery and allows them to determine what investigations will solve it. Accompanying assessments ensure that students have fully completed and understood the case study, showing that they have applied their knowledge of the concepts.
    Topics include:
    A Likely Story: Enzyme Inhibition
    An Unexplained Death: Carbohydrate Metabolism
    A Day at the Beach: Lipid Metabolism
    Runner's Experiment: Integration of Metabolism
    NEW!  pH Peril: pH and Amino Acid Structure
    Profound Relevance: Hemoglobin Regulation (Bohr Effect)
    Observation Over Intuition: Thermodynamics of Protein Folding
Additional Notable Revised Text Features
  • New graphics, design, and art
    The design of this edition retains the clean, somewhat minimalist, look that has been a hallmark of the textbook since Lubert Stryer first wrote the book in the 1970s. But in this edition, the book has added some graphic punch through its color palette and careful use of icons and other design elements.
    Updated clinical and evolutionary insight icons.
    NEW Industry Insight icon,
    which sits next to text that describes advances and research in areas like drug development, medicine, renewable energy, and sensor technology (Chapters 28, 14, 5, and 6, respectively).
    Many elements, like cell membranes, have been revised in every piece of art where they appear, again, to refresh and modernize the look of the textbook.
  • New learning objectives
    Each chapter opening page now includes a numbered list of learning objectives: statements that will help students organize their notes and assist their focus as they read through a chapter. To reinforce the connections between the chapter content and the learning objectives, the learning objectives are tied to some of the end-of-chapter problems.


  • New end of chapter active learning exercises
  • Biochemistry in Focus: Vignettes focused on Recent developments in biochemistry
    Chapter 5: Biofuel production from genetically engineered algae
    Chapter 8: The effect of temperature on enzymes and the color of Siamese cats
    Chapter 12: The curious case of cardiolipin;
    Chapter 17: New treatments for tuberculosis
    Chapter 20:  Hummingbirds and the pentose phosphate pathway
    Chapter 21: McArdle disease and skeletal muscle glycogen phosphorylase
    Chapter 25:Uridine plays a role in caloric homeostsis
    Chapter 27: Exercise alters muscle and whole-body metabolism;
    Chapter 32: Regulating gene expression through proteolysis


  • Problem-Solving Strategies Unpack one or two problems so that students can see step-by-step how to solve complex, often multi-part, biochemistry problems.
    Chapters 15–27: These strategies focus on the core metabolism chapters
    Chapters 8, 9, and 10: introduction to enzymes


  • NEW Think/Pair/Share. End of Chapter problems designed to be more open-ended and to require students to analyze and synthesize information from each chapter. The questions will work well as in-class activities and as small-group assignments either in or out of class using SaplingPlus.


  • New scientific content
    The authors have updated every chapter based on the latest basic and biomedical research, agricultural developments, and industrial breakthroughs. For example, techniques like mass spectrometry and cryo-electron microscopy are revealing that for many metabolic pathways or major parts of them, the involved enzymes actually form enormous enzyme complexes (see, for example, Section 16.1 [glycolysis], Section 17.2 [citric acid cycle], and Section 18.3 [oxidative phosphorylation]). These large structures facilitate the transfer of reaction intermediates, reduce undesirable side reactions, and enhance the catalytic properties of the enzymes.
  • The chapter on drug development has been revised and moved from its position at the end of the book to Chapter 28. Moving the drug development chapter near the end of the metabolism section highlights the importance of understanding the intricacies of metabolic pathways and the importance of developing drugs to combat disease and promote health.