Eleventh Edition   ©2015

An Introduction to Genetic Analysis

Anthony J.F. Griffiths (University of British Columbia) , Susan R. Wessler (University of California, Riverside) , Sean B. Carroll (University of Wisconsin; Howard Hughes Medical Institute) , John Doebley

  • ISBN-10: 1-4641-0948-6; ISBN-13: 978-1-4641-0948-5; Format: Cloth Text, 896 pages

LAUNCHPAD

Developed with extensive feedback from instructors and students, LaunchPad offers:

Pre-built Units for each chapter, curated by experienced educators, with media for each chapter organized and ready to assign or customize to suit your course.

All online resources for the text in one location, including:
LearningCurve adaptive quizzing (see below)—now with more questions at all levels

    New Problem-solving videos—step-by-step, whiteboard-style demonstrations of problems students often find difficult.

      Animations of genetic processes and experiments (six new)—every animation now includes assessment questions. Icons in the text showing students when to review them.

        Updated Unpacking the Problem problem-solving tutorials, on topics students struggle with, including:

          • Chi-square Analysis (Chs. 4/5)
          • Pedigree Analysis (Ch. 6)
          • Epistasis (Ch. 6)
          • Molecular Biology Techniques (Ch. 10)
          • Mutations on Gene Expression (Ch. 12)
          • Development (Ch. 13)
          • Population Genetics (Ch. 18)
          • Quantitative Genetics (Ch. 19)

              Online versions of the new edition’s expanded end-of-chapter problem sets, plus and larger test bank

              Intuitive and useful analytics, with a Gradebook that reveals how the class is doing individually and as a whole.

              A streamlined and intuitive interface that lets instructors build an entire course in minutes.


              LearningCurve

              In a game-like format, LearningCurve adaptive and formative quizzing provides an effective way to get students involved in the coursework. With an expanded base of questions at all level for this edition, LearningCurve offers:

              • A unique learning path for each student, with quizzes shaped by each individual’s correct and incorrect answers.
              • A Personalized Study Plan, to guide students’ preparation for class and for exams.
              • Feedback for each question with live links to relevant e-book pages, guiding students to the reading they need to do to improve their areas of weakness.


              NEW CONTENT

              New Chapter 1
              The new edition begins with four current stories of how genetics is currently being applied to research into human disease, mutation rates and reproduction, evolution, and agriculture. These stories introduce basic concepts while connecting the course to immediate, real-world issues piquing student interest in genetics. The chapter still offers a short history of the field, but without an explicit overview of genetics topics.

              Thoroughly Revised Chapter 14, Genomes and Genomics
              New introduction
              features real-life application of medical genomics.

              New coverage of:

              • Illumina sequencing
              • RNA-seq
              • Non-coding functional elements in the genome, including the ENCODE project

                Expanded coverage of comparative genomics:

                • Section 14.5 Comparative Genomics of Humans with Other Species includes a new example: the vitellogenin gene
                • Section 14.6 Comparative Genomics and Human Medicine includes a new section on exome sequencing and its role in human medicine


                  Additional New Coverage Highlights

                  • A new introduction to forward genetics and the role of genetic analysis in identifying traits of single-gene inheritance (Ch 2)
                  • Concepts of dominance and recessiveness now explained in terms of haplosufficiency and haploinsufficiency (Ch 2)
                  • Revised section on chi-square analysis (Ch. 4)
                  • New coverage of horizontal and vertical transmission (Ch. 5)
                  • Updated coverage of dynamic chromatin, including chromatin remodeling, histone modification, and histone variants (Ch. 12)
                  • Genomic surveillance of transposable elements (pi-clusters and CRISPR loci) added. (Ch. 15)
                  • Nucleotide excision repair (NER) pathway updated to reflect current knowledge (Ch. 16)
                  • New coverage of MacDonald and Kreitman method for detecting positive selection (Ch. 20)

                   New Learning Objectives
                  Each chapter begins with a list of specific learning outcomes, giving students a clear roadmap/study plan for navigating the material, reviewing and reinforcing key ideas, and preparing for exams. Chapter coverage and the end-of-chapter questions give instructors plenty of opportunities for outcomes-based assessments.
                  Expanded Assessment
                • More End-of-Chapter problems at all levels, in the book and online in LaunchPad
                • More text bank and LearningCurve adaptive quizzing questions in LaunchPad
                • Animations now include assessment questions