Skip to Main Content
  • Instructor Catalog
  • Instructor Community
  • Student Store
  • USUnited States Store
Instructor Catalog Instructor Catalog
    • I'M AN INSTRUCTOR

    • I'M A STUDENT
  • help
  • search
  • minicart
    0
    • USUnited States Store

Find what you need to succeed.

search icon
  • Our Story

    Our Story

    back
    • Our Mission
    • Our Leadership
    • Learning Science
    • Sustainability
    • Careers
    • Diversity, Equity, and Inclusion
    • Accessibility
  • Discipline

    Discipline

    back
    • Astronomy Biochemistry Biology Chemistry College Success Communication Economics Electrical Engineering English Environmental Science Geography Geology History Mathematics Music & Theater Nutrition and Health Philosophy & Religion Physics Psychology Sociology Statistics Value
  • Digital

    Digital

    back
    • Digital Offerings
    • Achieve
    • LaunchPad
    • E-books
    • iOLab
    • iClicker
    • Inclusive Access
    • Lab Solutions
    • LMS Integration
    • Curriculum Solutions
    • Training and Demos
    • First Day of Class
  • Solutions

    Solutions

    back
    • Administrators
    • Affordable Solutions
    • Badging & Certification
    • iClicker and Your Content
    • Lab Solutions
    • Student Store
    • TradeUp
  • News & Media

    News & Media

    back
    • News & Media
  • Contact Us

    Contact Us

    back
    • Contact Us & FAQs
    • Find Your Rep
    • Training and Demos
    • First Day of Class
    • Booksellers
    • Macmillan International Support
    • International Translation Rights
    • Request Permissions
    • Report Piracy
  1. Home
  2. Chemistry
  3. Posttranslational Modification of Proteins
  • About
  • Preview
  • Contents
  • Authors
Posttranslational Modification of Proteins by Christopher Walsh - First Edition, 2006 from Macmillan Student Store
Find Your Rep

Posttranslational Modification of Proteins

Expanding Nature's InventoryFirst Edition| ©2006 Christopher Walsh

The number of protein isoforms in proteomes can be two to three orders of magnitude higher than the number of genes in the genomes. This is in large part due to posttranslational modifications of proteins that provide covalent alterations to protein backbones and side chains that increase proteome c...
The number of protein isoforms in proteomes can be two to three orders of magnitude higher than the number of genes in the genomes. This is in large part due to posttranslational modifications of proteins that provide covalent alterations to protein backbones and side chains that increase proteome complexities. Greater than 5% of the genes in the human genome encode enzymes that perform such modifications, including hundreds of protein kinases and opposing phosphatases, ubiquitinyl ligases, acetylases and deacetylases, methyl transferases and glycosyl transferases. The major classes of posttranslational modifications (PTM) are codified according to types of residues modified, underlying chemistry, PTM catalysts, and biological consequences. This is the first comprehensive treatment of this burgeoning area of proteome diversification.
Read more
Students - Buy or Rent

  • Format
Hardcover from C$36.99

ISBN:9780974707730

Read and study old-school with our bound texts.

Retail:C$36.99

Rent until 04/30/2023

Retail:C$42.99

Rent until 06/09/2023

Retail:C$50.99

Rent until 07/29/2023

Retail:C$78.99

Rent until 01/25/2024

Retail:C$154.99 Wholesale:C$124.06


Home Reviews
Posttranslational Modification of Proteins by Christopher Walsh - First Edition, 2006 from Macmillan Student Store

The number of protein isoforms in proteomes can be two to three orders of magnitude higher than the number of genes in the genomes. This is in large part due to posttranslational modifications of proteins that provide covalent alterations to protein backbones and side chains that increase proteome complexities. Greater than 5% of the genes in the human genome encode enzymes that perform such modifications, including hundreds of protein kinases and opposing phosphatases, ubiquitinyl ligases, acetylases and deacetylases, methyl transferases and glycosyl transferases. The major classes of posttranslational modifications (PTM) are codified according to types of residues modified, underlying chemistry, PTM catalysts, and biological consequences. This is the first comprehensive treatment of this burgeoning area of proteome diversification.

Features

New to This Edition

"Christopher Walsh, an acclaimed scientist, has written yet another outstanding book. It surveys the vast field of chemical modifications that proteins undergo in living cells. The book's depth of coverage and clarity of exposition will make it an indispensable text for both students and active researchers."
—Alexander Varshavsky, Smits Professor of Cell Biology, California Institute of Technology

"Walsh effectively covers all of the major PTMs with a care for detail that is both admirable and captivating. The enzymes involved in generating PTMs are described with clarity and sufficient detail so that both novices and experts in this field are sure to learn much from this book."
—Benjamin F. Cravatt III, The Skaggs Institute for Chemical Biology, The Scripps Research Institute

"Walsh has coalesced the dizzying array of posttranslational modifications into a small subset of reactions. It is written with a concise chemical logic and Walsh’s typical flair that makes it a pleasure to read."
—Michael A. Marletta, Professor of Chemistry, Professor of Biochemistry and Molecular Biology, University of California, Berkeley

"This book covers the wide range of posttranslational modifications found in Nature, many of which have been discovered relatively recently as a result of improved detection methods. As such, it is a very timely book that may be used either as a reference entry into a certain field or as a comprehensive collection of the astonishing structural and functional variety of these modifications. The author treats the subject from the perspective of both the mechanism of formation of these protein conjugates and their biological function in processes like signal transduction and enzymatic catalysis. As expected from Walsh, each topic is treated clearly with an eye for important details as well as the more overarching implications. Several very interesting links are made between various modification processes and their roles in biological processes that tie the at first glance heterogeneous collection of posttranslational modifications very nicely together."
—Wilfred van der Donk, University of Illinois at Urbana-Champaign

"The central dogma of gene -> protein -> function has suffered continuing amendments by protein posttranslational modifications.  Walsh brings expert skills in enzymology, protein function and not least, clear writing to this succinct overview of a burgeoning field. This book deserves a place on the desk of every serious student (and professional) of metabolism, protein structure and cellular signaling. A highlight for this reviewer is the attention to posttranslational regulation as targets for pharmaceutical intervention. Walsh does a superb job of weaving whole fabric from these still-developing pathways."
—Vern L. Schramm, Ruth Merns Chair and University Professor, Albert Einstein College of Medicine 

Posttranslational Modification of Proteins by Christopher Walsh - First Edition, 2006 from Macmillan Student Store

Posttranslational Modification of Proteins

First Edition| ©2006

Christopher Walsh

Digital Options

Posttranslational Modification of Proteins by Christopher Walsh - First Edition, 2006 from Macmillan Student Store

Posttranslational Modification of Proteins

First Edition| 2006

Christopher Walsh

Table of Contents

1. Introduction
2. Phosphorylation and dephosphorylation
3. Sulfurylation of proteins
4. Sulfur redox transformations in proteins
5. Protein methylation
6. Protein acetylation
7. Lipid modifications of proteins
8. Posttranslational proteolysis
9. Ubiquitin and ubiquitin like protein tags
10. Protein glycosylation
11. ADP ribosylation of proteins
12. Protein hydroxylation
13. Automodification reactions of proteins
14. Swinging arms for covalent tethering of coenzymes
15. Protein carboxyaltion and amidation

References
Index

Posttranslational Modification of Proteins by Christopher Walsh - First Edition, 2006 from Macmillan Student Store

Posttranslational Modification of Proteins

First Edition| 2006

Christopher Walsh

Find Your Rep

Authors

Christopher Walsh

Professor Walsh is currently the Hamilton Kuhn Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. He is one of the leading enzymologists in the world. He has elucidated the catalytic mechanisms of a wide variety of enzymes including flavoproteins and other redox enzymes. He has also pioneered the design of mechanism-based enzyme inhibitors (or "suicide" substrates). His work has found practical application in the design of antibacterial agents, anticonvulsive agents, plant growth regulators, and antitumor drugs. His current focus is on the biosynthesis and mechanism of action of antibiotics and bacterial siderophores. He has published over 600 scientific articles and his book, Enzymatic Reaction Mechanisms, has educated generations of enzymologists.

Professor Walsh's accomplishments have been recognized through numerous awards which include the Eli Lilly Award in Biochemistry, the Arthur C. Cope Scholar Award in Organic Chemistry, the Repligen Award in Biological Chemistry, and the Alfred Bader Award in Bioorganic and Bioinorganic Chemistry. He is a member of the National Academy of Sciences, the Institute of Medicine, and the American Academy of Arts and Sciences.

Posttranslational Modification of Proteins by Christopher Walsh - First Edition, 2006 from Macmillan Student Store

Posttranslational Modification of Proteins

First Edition| 2006

Christopher Walsh

Related Titles

Available Demos

Select a demo to view:

Achieve icon Sample Achieve

We are happy to offer free Achieve access in addition to the
physical sample you have selected. Sample this version now as
opposed to waiting for the physical edition.

We are happy to offer free Achieve access in
addition to the physical sample you have
selected. Sample this version now as opposed to
waiting for the physical edition.

Learn more about Achieve
  • Privacy Notice
  • //
  • Ads & Cookies
  • //
  • Terms of Use
  • //
  • Piracy
  • //
  • Accessibility
  • //
  • Code of Conduct
  • //
  • Site Map
  • //
  • Customer Support
  • Macmillan Learning Facebook icon
  • Macmillan Learning Twitter icon
  • Macmillan Learning Youtube icon
  • Macmillan Learning Linkedin icon
  • Macmillan Learning Instagram icon
We are processing your request. Please wait...