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Biological Physics
with New Art by David GoodsellFirst Edition| ©2013 Philip Nelson
Biological Physics focuses on new results in molecular motors, self-assembly, and single-molecule manipulation that have revolutionized the field in recent years, and integrates these topics with classical results. The text also provides foundational material for the emerging field of nanotec...
Biological Physics focuses on new results in molecular motors, self-assembly, and single-molecule manipulation that have revolutionized the field in recent years, and integrates these topics with classical results. The text also provides foundational material for the emerging field of nanotechnology.
Biological Physics is built around a self-contained core geared toward undergraduate students who have had one year of calculus-based physics. Additional “Track-2” sections contain more advanced material for senior physics majors and graduate students.
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Biological Physics is built around a self-contained core geared toward undergraduate students who have had one year of calculus-based physics. Additional “Track-2” sections contain more advanced material for senior physics majors and graduate students.

Biological Physics focuses on new results in molecular motors, self-assembly, and single-molecule manipulation that have revolutionized the field in recent years, and integrates these topics with classical results. The text also provides foundational material for the emerging field of nanotechnology.
Biological Physics is built around a self-contained core geared toward undergraduate students who have had one year of calculus-based physics. Additional “Track-2” sections contain more advanced material for senior physics majors and graduate students.
Features
Looks at the big picture. Students learn how the lessons of biological physics pertain to all fields of science and go beyond that to consider the relevance of those lessons to their everyday lives.
Conceptual. The book looks at the reasons why each mathematical step is taken, giving students the understanding that will help them to explore on their own.
No black boxes. Most mathematical results are derived from first principles.
Real data. Every chapter presents actual laboratory data; the text shows the students how to construct models based on simple physical ideas that fit the data.
“Excursion” sections that complement most chapters contain articles by leading experimentalists and historical or cultural essays.
Conceptual. The book looks at the reasons why each mathematical step is taken, giving students the understanding that will help them to explore on their own.
No black boxes. Most mathematical results are derived from first principles.
Real data. Every chapter presents actual laboratory data; the text shows the students how to construct models based on simple physical ideas that fit the data.
“Excursion” sections that complement most chapters contain articles by leading experimentalists and historical or cultural essays.
New to This Edition
In the Updated Edition
New end-of-chapter problems at all levels for every chapter, giving instructors fresh new options for assignments and exams
Updated information in Chapter 10, Enzymes and molecular machines, for a thoroughly up-to-date look at our rapidly evolving understanding of molecular motors
New paperback format
"Nelson says that his book is for 'life science students who are willing to use calculus' and for 'physical science and engineering students who are willing to think about cells'. And indeed, his book should educate and intrigue both groups. Particularly impressive is the subtle way that topics that often cause the eyes of even the most diligent student to glaze over are made to seem not just interesting to read about but compelling to learn.... Moreover, although much emphasis is placed on understanding ideas, the text does not allow anyone to forget that some real equations need to be mastered if such an understanding is to be satisfying and widely applicable.
Another good aspect of this book is that it is right up to date in the topics and examples that it covers. Many relatively recent ideas, such as the use of free-energy surfaces for understanding protein folding and of optical tweezers for probing muscle action, are covered in depth, with at least some references to the original literature. There are frequent comments about the way that modern ideas and techniques have emerged. As Nelson cleverly shows, many of the most important scientific breakthroughs have come about unexpectedly through just the type of interdisciplinary studies that this book promotes.
—Nature 432, 444-445 (25 November 2004)
"This creative and insightful textbook brings definition to the field....
These days physical scientists need to understand more biology, just as biological scientists need to understand more physics. Nelson's engaging and satisfying book opens the doors in both directions. It will intrigue both the student and the professor.""Phil Nelson has crafted a marvelous text on biological physics. Not only is it authoritative and up to date; it's that rarity of rarities, a textbook that is actually fun to read. I've already learned a lot from it and can't wait to read more." -- Steven Strogatz, Professor of Applied Mathematics, Cornell University, and author of Nonlinear Dynamics and Chaos—excerpt from the review in American Journal of Physics
"The proposed book by Nelson will fill a clear need. Discussion revolves around central ideas, and the ideas are developed clearly. Moreover, Nelson has a very engaging style, with effective use of humor and example. We are fortunate that a person with his deep knowledge of the workings of nature and appreciation for her beauty has devoted so much time toward the development of his course on biophysics." --William Parke, Physics Dept., George Washington University
"I have found it difficult to teach my class to both graduate and undergraduate students at the same time. The use of [Nelson's] Track 2 option is perfect for my students. This way I can use one text that will be readable by my undergraduate students while it's still challenging to my graduate students. Dr. Nelson succeeds in explaining difficult concepts in words and then presents the mathematics in a clear way." -- Daniel Kim-Shapiro, Physics Dept., Wake Forest University
"I applaud the author for undertaking the task to develop this course and, even more so, to write this book. There are few as capable as Nelson of carrying this out successfully. He is an excellent writer, being both entertaining and clear. In short, I think you have a future gem on your hands." -- Fred MacKintosh, Dept. of Physics, Princeton University
"Dr. Nelson has done a splendid job conveying how principles of physics apply to biological systems. The book is exceptionally multifaceted, allowing the instructor to gear it toward students from a variety of backgrounds. I think Biological Physics will be a winner!" -- Donald Jacobs, Cal State-Northridge
"Overall I found the choice of topics to be quite interesting and appropriate, and the presentation of the material attractive. The author writes well, and he employs an appealing physical style of presentation, in the conversational Feynman Lectures tradition, rather than a very mathematical style or the fact-heavy style of a university biology textbook. He places emphasis on simple arguments, dimensional analysis and tabletop demonstrations of everyday experience. He chooses good examples. This is the kind of thing that I believe a biological phyiscs course should aim to teach." -- Steve Hagen, University of Florida
"The simplicity of physics is stressed and the utility of making quantitative predictions... The big picture is explained and put in focus... An elegant presentation that is physically very insightful.
Nelson has done a splendid job conveying how principles of physics apply to biological systems. The intended book develops a logical thread of thought from one idea into another that weaves a big picture for the reader... The book is exceptionally multifaceted, allowing the instructor to gear it
toward students from a variety of backgrounds." -- DONALD JACOBS, Department of Physics and Astronomy, California State University, Northridge
"The author writes well, and he employs an appealing physical style of presentation, in the conversational Feynman Lectures tradition, rather than a very mathematical style, or the fact-heavy style of a university biology text. He places emphasis on simple arguments, dimensional analysis, and
tabletop demonstrations or everyday experience. He chooses good examples of biological systems where simple physical arguments can provide insight into the mechanisms or constraints under which these systems operate. Thisis the kind of thing that I believe a biological physics course should aim
to teach." -- STEVE HAGEN, Physics Department, University of Florida
"I applaud the author for undertaking the task to develop this course and, even more so, to write this book. There are few as capable as Nelson of carrying this out successfully. He is an excellent writer, both entertaining and clear." -- FRED MACKINTOSH, Division of Physics and Astronomy, Vrije Universiteit Amsterdam; Adjunct Associate Editor for Biological Physics, Physical Review Letters
"I have found it difficult to teach my class to both graduate and undergraduate students at the same time. The use of [Nelson's] Track 2 option is perfect for my students. This way I can use one text that will be readable by my undergraduate students while it's still challenging to my graduate students. Dr. Nelson succeeds in explaining difficult concepts in words and then presents the mathematics in a clear way." -- DANIEL KIM-SHAPIRO, Physics Dept., Wake Forest University
"The book by Nelson will fill a clear need. Discussion revolves around central ideas, and the ideas are developed clearly. Moreover, Nelson has a very engaging style, with effective use of humor and example. We are fortunate that a person with his deep knowledge of the workings of Nature and appreciation for her beauty has devoted so much time toward the development of his course on biophysics." --WILLIAM PARKE, Physics Dept., George Washington University
"Phil Nelson's book is simultaneously interesting, humorous and full of deep insights into the coupling between physics and biology. It was a pleasureto read every page and rederive each equation in his book and then use it in several courses. It is full of ideas of interest to physics and biology students alike. It is especially satisfying to see how the use of single molecule techniques (and associated modeling) complements advances from structural biology and solution biochemistry. I think it is a great addition to the field." -ROB PHILLIPS, California Institute of Technology
"Understanding the mechanisms behind cellular level transport, thermodynamics, macromolecular interactions, and nerve conduction is a staggering challenge to aged experts and novice students. Biological Physics synthesizes these concepts elegantly in a way that is accessible and interesting to experts and students alike. Nelson's book provides a foundation that is crucial to the future of physics, mathematics, and biomedical engineering. And what makes the text truly special is its ability to stimulate the reader's curiosity." - ERIC NAUMAN, Tulane University

Biological Physics
First Edition| ©2013
Philip Nelson
Digital Options

Biological Physics
First Edition| 2013
Philip Nelson
Table of Contents
I. Mysteries, Metaphors, Models
1. What the ancients knew
2. What’s inside cells
2. What’s inside cells
II. Diffusion, Dissipation, Drive
3. The molecular dance
4. Random walks, friction, and diffusion
5. Life in the slow lane: The low Reynolds-number world
6. Entropy, temperature, and free energy
7. Entropic forces at work
8. Chemical forces and self-assembly
III. Molecules, Machines, Mechanisms
3. The molecular dance
4. Random walks, friction, and diffusion
5. Life in the slow lane: The low Reynolds-number world
6. Entropy, temperature, and free energy
7. Entropic forces at work
8. Chemical forces and self-assembly
III. Molecules, Machines, Mechanisms
9. Cooperative transitions in macromolecules
10. Enzymes and molecular machines
11. Machines in membranes
12. Nerve impulses
10. Enzymes and molecular machines
11. Machines in membranes
12. Nerve impulses
Global list of symbols and units
Numerical values
Index
Numerical values
Index
Authors

Philip Nelson
Philip Nelson is Professor of Physics at the University of Pennsylvania. He received his A.B. from Princeton University (1980) and Ph.D. from Harvard University (1984). Dr. Nelson serves on the Biophysical Society’s Education Committee; he received Penn’s highest teaching award in 2001, in part for creating the course that formed the basis for this book. Dr. Nelson was recently elected a Fellow of the American Physical Society.
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Biological Physics
First Edition| 2013
Philip Nelson
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